Converting protein sequence to image for classification with convolutional neural network
Subject Areas : Generalreza ahsan 1 , mansour ebrahimi 2 * , dianat dianat 3
1 - عضو هیات علمی
2 -
3 -
Keywords: : Converting protein sequence to image, Gabor filter, Convolution Neural Network, Protein classification.,
Abstract :
Since methods for sequencing machine learning sequences were not successful in classifying healthy and cancerous proteins, it is imperative to find a way to represent these sequences to classify healthy and ill individuals with deep learning approaches. In this study different methods of protein sequence representation for classification of protein sequence of healthy individuals and leukemia have been studied. Results showed that conversion of amino acid letters to one-dimensional feature vectors in classification of 2 classes was not successful and only one disease class was detected. By changing the feature vector to colored numbers, the accuracy of the healthy class recognition was slightly improved. The binary protein sequence representation method was more efficient than the previous methods with the initiative of sequencing the sequences in both one-dimensional and two-dimensional (image by Gabor filtering). Protein sequence representation as binary image was classified by applying Gabor filter with 100% accuracy of the protein sequence of healthy individuals and 98.6% protein sequence of those with leukemia. The findings of this study showed that the representation of protein sequence as binary image by applying Gabor filter can be used as a new effective method for representation of protein sequences for classification
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